Plant Transcription Factor Database
Previous version: v3.0
Ipomoea trifida
M-type_MADS Family
Species TF ID Description
Itr_sc000012.1_g00024.1M-type_MADS family protein
Itr_sc000030.1_g00032.1M-type_MADS family protein
Itr_sc000037.1_g00038.1M-type_MADS family protein
Itr_sc000037.1_g00039.1M-type_MADS family protein
Itr_sc000043.1_g00019.1M-type_MADS family protein
Itr_sc000043.1_g00031.1M-type_MADS family protein
Itr_sc000055.1_g00016.1M-type_MADS family protein
Itr_sc000093.1_g00005.1M-type_MADS family protein
Itr_sc000154.1_g00001.1M-type_MADS family protein
Itr_sc000188.1_g00017.1M-type_MADS family protein
Itr_sc000215.1_g00020.1M-type_MADS family protein
Itr_sc000215.1_g00021.1M-type_MADS family protein
Itr_sc000237.1_g00021.1M-type_MADS family protein
Itr_sc000290.1_g00012.1M-type_MADS family protein
Itr_sc000297.1_g00011.1M-type_MADS family protein
Itr_sc000322.1_g00007.1M-type_MADS family protein
Itr_sc000368.1_g00011.1M-type_MADS family protein
Itr_sc000417.1_g00055.1M-type_MADS family protein
Itr_sc000453.1_g00004.1M-type_MADS family protein
Itr_sc000464.1_g00003.1M-type_MADS family protein
Itr_sc000467.1_g00001.1M-type_MADS family protein
Itr_sc000540.1_g00001.1M-type_MADS family protein
Itr_sc000582.1_g00010.1M-type_MADS family protein
Itr_sc000582.1_g00011.1M-type_MADS family protein
Itr_sc000700.1_g00006.1M-type_MADS family protein
Itr_sc000817.1_g00011.1M-type_MADS family protein
Itr_sc001035.1_g00011.1M-type_MADS family protein
Itr_sc001057.1_g00006.1M-type_MADS family protein
Itr_sc001065.1_g00001.1M-type_MADS family protein
Itr_sc001072.1_g00007.1M-type_MADS family protein
Itr_sc001111.1_g00001.1M-type_MADS family protein
Itr_sc001131.1_g00002.1M-type_MADS family protein
Itr_sc001153.1_g00017.1M-type_MADS family protein
Itr_sc001190.1_g00001.1M-type_MADS family protein
Itr_sc001287.1_g00001.1M-type_MADS family protein
Itr_sc001287.1_g00006.1M-type_MADS family protein
Itr_sc001480.1_g00006.1M-type_MADS family protein
Itr_sc001510.1_g00006.1M-type_MADS family protein
Itr_sc001586.1_g00003.1M-type_MADS family protein
Itr_sc001686.1_g00001.1M-type_MADS family protein
Itr_sc001686.1_g00005.1M-type_MADS family protein
Itr_sc001803.1_g00002.1M-type_MADS family protein
Itr_sc001843.1_g00001.1M-type_MADS family protein
Itr_sc001957.1_g00003.1M-type_MADS family protein
Itr_sc001975.1_g00001.1M-type_MADS family protein
Itr_sc001975.1_g00002.1M-type_MADS family protein
Itr_sc001975.1_g00003.1M-type_MADS family protein
Itr_sc001975.1_g00004.1M-type_MADS family protein
Itr_sc002099.1_g00011.1M-type_MADS family protein
Itr_sc002179.1_g00001.1M-type_MADS family protein
Itr_sc002179.1_g00002.1M-type_MADS family protein
Itr_sc003031.1_g00001.1M-type_MADS family protein
Itr_sc003209.1_g00001.1M-type_MADS family protein
Itr_sc003236.1_g00002.1M-type_MADS family protein
Itr_sc003409.1_g00003.1M-type_MADS family protein
Itr_sc003629.1_g00004.1M-type_MADS family protein
Itr_sc003720.1_g00001.1M-type_MADS family protein
Itr_sc004336.1_g00001.1M-type_MADS family protein
Itr_sc004867.1_g00001.1M-type_MADS family protein
Itr_sc005209.1_g00001.1M-type_MADS family protein
Itr_sc005890.1_g00001.1M-type_MADS family protein
Itr_sc006005.1_g00001.1M-type_MADS family protein
Itr_sc006005.1_g00006.1M-type_MADS family protein
Itr_sc006005.1_g00007.1M-type_MADS family protein
Itr_sc006559.1_g00002.1M-type_MADS family protein
Itr_sc008111.1_g00001.1M-type_MADS family protein
Itr_sc013484.1_g00001.1M-type_MADS family protein
Itr_sc032379.1_g00001.1M-type_MADS family protein
Itr_sc032675.1_g00001.1M-type_MADS family protein
Itr_sc046742.1_g00001.1M-type_MADS family protein
Itr_sc056773.1_g00001.1M-type_MADS family protein
Itr_sc064431.1_g00001.1M-type_MADS family protein
Itr_sc068451.1_g00001.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513